tecovirimat will improve the level or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Keep an eye on for adverse results if coadministered with sensitive substrates of such enzymes.
enasidenib will increase the level or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Enasidenib (a weak CYP2C19 inhibitor) may well maximize systemic publicity of sensitive CYP2C19 substrates. Observe and adjust dose of substrate as clinically indicated.
Prescribers must recommend caregivers that they hope to generally be knowledgeable quickly if a affected individual develops any new conclusions which are not standard from the client’s characteristic seizure episode
Lencapavir (a reasonable CYP3A4 inhibitor) might maximize CYP3A4 substrates initiated inside 9 months following last SC dose of lenacapavir, which can raise prospective danger of adverse reactions of CYP3A4 substrates.
Diazepam may interfere with metabolism of substrates for CYP2C19 and CYP3A4 leading to a possible drug-drug interaction
All medicines have threats in addition to Positive aspects. Stay knowledgeable with regards to the possible Unwanted side effects of BRIVIACT
These are not all of the doable Uncomfortable side effects of BRIVIACT. click here For more info, ask your healthcare supplier or pharmacist. Inform your Health care company about any aspect effect that bothers you or that doesn't go away.
Reserve concomitant prescribing of those medication in patients for whom other cure alternatives are inadequate. Limit dosages and durations to your bare minimum essential. Observe intently for indications of respiratory depression and sedation.
Stay clear of or substitute A different drug for these drugs when feasible. Evaluate for loss of therapeutic influence if medication should be coadministered. Regulate dose As outlined by prescribing info if desired.
Instruct individuals to inform their healthcare service provider if they are breastfeeding or plan to breastfeed; instruct breastfeeding sufferers to watch their infants for extreme sedation, lousy feeding and weak fat get, and to seek health-related attention if they see these symptoms
sparsentan will decrease the extent or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and decreases efficacy associated with these substrates.
conivaptan will boost the level or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Comment: Teduglutide may well enhance absorption of concomitant PO medicines; warning with with medications requiring titration or All those using a narrow therapeutic index; dose adjustment may very well be needed.
primidone will decrease the extent or result of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.